Trichinella spiralis and Larval Cytotoxicity After Infection with CCR3 Is Required for Tissue Eosinophilia

Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections.

Enteric nematode infections are characterized by both peripheral and tissue eosinophilia. The cytokine interleukin (IL)-5 is considered a critical factor in the proliferation and recruitment of eosinophils, however, studies suggest it plays little role in host defence, at least during primary Trichinella spiralis infections. Less is known concerning its role in host defence or in the inflammato...

Trichinella spiralis: phospholipase in sensitized mice after challenge.

LARSH, JOHN E., JR., OTTOLENGHI, ATHOS, AND WEATHERLY, NORMAN F. 1975. Trichinella spiralis: Phospholipase in sensitized mice after challenge. Experimental Parasitology 37, 233-238. Mice given three sensitizing infections with Trichinella spiralis and then challenged with 400 larvae showed greatly elevated phospholipase B levels in the small intestine from one through 20 days after challenge; b...

Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.

To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody production in normal mice. The kinetics of blood eosinophilia, worm burden after...

Tissue and blood eosinophilia in mast cell-deficient Sl/Sld mice infected with Trichinella spiralis.

Larval viability and serological response in horses with long-term Trichinella spiralis infection.

The horse is considered an aberrant host for the nematode parasite Trichinella spiralis, and many aspects of the biology and epidemiology of Trichinella infection in the horse are poorly understood. It has been reported that experimentally-infected horses produce a transient serological response to infection and that muscle larvae are cleared more rapidly than in parasite-adapted hosts such as ...